How to use Lenacapavir for HIV prevention

Lenacapavir is a breakthrough in HIV prevention, offering a new option for people who struggle with existing methods. As South Africa intensifies efforts to end AIDS as a public health threat by 2030, this long-acting injection is expected to play a critical role.

What is Lenacapavir?

Lenacapavir is a preventive HIV medicine administered as an injection every six months. It is not a vaccine, but a long-acting treatment that reduces the risk of HIV infection. Its twice-yearly dosing makes it more convenient than daily oral prevention methods.

Government has identified it as a major innovation, with plans for widespread rollout as part of a broader, people-centred HIV prevention strategy. 

Who should use it?

Lenacapavir is designed for people at higher risk of HIV infection, especially those who face barriers to daily medication. Priority groups include:

• Adolescent girls and young women
• Pregnant and breastfeeding women
• Sex workers
• Men who have sex with men, transgender people and people who inject drugs 

These populations are often underserved by current HIV prevention programmes, making this option particularly valuable.

How to access Lenacapavir

To access the injection, individuals should:

1. Visit a public health clinic offering HIV prevention services
2. Consult a healthcare provider about eligibility
3. Undergo HIV testing and counselling
4. Receive the injection every six months if eligible

Consistent follow-up is important to maintain protection.

Why is it important?

Lenacapavir offers several advantages:

• Long-lasting protection with just two injections a year
• Improved adherence compared to daily pills
• Expanded prevention choices
• Better reach among vulnerable groups

It strengthens existing prevention efforts and supports South Africa’s goal of reducing new HIV infections.

Lenacapavir is a gamechanger in HIV prevention. By simplifying treatment and widening access, it provides new hope for individuals at risk and helps accelerate progress towards ending AIDS as a public health threat.

This information was supplied by the Department of Health.